Computational Prediction of Protein Functional Sites
Complementary computational approaches that predict functional residues in proteins by integrating sequential, structural and physiochemical features
POOL
POOL (Partial Order Optimum Likelihood) is an ML algorithm designed to identify functionally important residues in proteins, particularly those involved in catalysis or ligand binding.
GRASP-Func
GRASP-Func (Graph Representation of Active Sites for the Prediction of Function) operates by focusing on the local active site of enzymes rather than the overall fold or sequence.